• October 23, 2023

Improving the 3+3 Design for Dose-Finding in Cancer Clinical Trials

3+3 Design Example for Dose-Finding in Cancer Clinical Trials

The 3 + 3 design is a popular choice for dose-finding in phase 1 cancer clinical trials. It is easy to implement and has good statistical properties.

However, it suffers from poor targeting of true MTD and the inability to de-escalate once excessive DLTs are observed — leading to long trial durations. Alternative model-based designs exist that can improve on this limitation.

The Design

Many oncology phase 1 trials use the traditional 3+3 design. This rule-based design does not require any modeling of the dose-toxicity relationship, and proceeds by allowing cohorts of three patients to be treated at increasing dosage levels that are predefined in advance. The initial dose level is based on extrapolation from animal toxicology data, and the subsequent doses are stepped up to achieve an MTD defined in advance.

While the traditional 3+3 design is simple to implement, it has significant limitations including slow pharmacokinetic titration, poor targeting of true MTD, and lack of flexibility to target alternate DLT rates. Alternative designs have been shown to be more efficient, accurate, and safe, and to produce results that more closely match clinical and theoretical true dose-toxicity relationships.

Among the most commonly used alternatives to the traditional 3+3 design are accelerated titration and continuous reassessment methods. We will describe these methods in more detail in future blogs. In simulation, these models have been shown to outperform the traditional 3+3 design in terms of MTD identification and speed of titration.

Dose Escalation

The conventional 3+3 design uses a pre-specified value of the probability that a given dose will cause DLT to select patients for subsequent cohorts. However, this approach is known to be suboptimal.

It has been shown that a CRM, which calculates the probability of DLT for each patient cohort based on the data of all previous cohorts, performs much better than the 3+3 design. It is also a relatively simple and straightforward method to implement. We have developed a freely-available macro to facilitate the implementation of the CRM in Microsoft Excel software.

There are a number of alternative methods to the 3+3 design that use a more adaptive and Bayesian approach to dose escalation. For example, accelerated titration designs and modified continual reassessment methods are designed to expose fewer patients to subtherapeutic dose levels. However, it is yet to be established whether they result in shorter trial durations.

Dose De-Escalation

Until recently, the traditional 3+3 design has been the preferred approach to conducting phase I clinical trials for cytotoxic drugs and molecularly targeted agents. This rule-based method requires no modeling of the dose-toxicity curve and proceeds with cohorts of three patients. Each successive cohort is treated with a dose level that has been pre-specified and is either extrapolated from animal toxicological data or is believed to be safe based on previous clinical trial experience.

However, the 3+3 method has been shown to be inferior to model-based methods in terms of estimating MTDs and determining recommended phase II doses (RP2Ds). It is also less efficient than adaptive/Bayesian designs.


Using the traditional 3+3 design, physicians sequentially enrol three patients into cohorts treated at increasing dose levels. If no dose-limiting toxicities (DLTs) are observed, the next three patients are enrolled at the next higher dose level. This process continues until one of the six doses tested imposes an unacceptable amount of DLTs on the patient population.

In the diagram above, you can click alternately on the period dividers between periods 5 and 6, to see what the dose-survival curve looks like at each dose level. Note that the 80% confidence band for DLTs straddles a fine red line at dose level 6, suggesting that a stop rule should be activated.

Several model-based design methods have been proposed to improve on the simple up-and-down approach illustrated here. In simulations, STARPAC and the continual reassessment method have performed better than 3+3 in terms of estimating the MTD and minimizing the number of declined patients. Both of these designs use the same model-based knowledge of toxicity rate at each dose level, but also allow clinicians to take into account their ethical concern about overdosing patients.

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  • October 16, 2023

Unraveling the Phenomenon: A Closer Look at 에볼루션파워볼 파싱알

Understanding 에볼루션파워볼 파싱알: An In-Depth Review

Wouldn’t it be great to get first-hand insight into the world of 에볼루션 파워볼 파싱알? What if I told you we could unravel the complexities together? Hold on, because it’s about to get exciting!

What is 에볼루션파워볼 파싱알?

The term “에볼루션파워볼 파싱알” is vastly becoming popular in the virtual world. But what does it actually signify? As a enthusiast, you might have a fair idea. But for those unacquainted (don’t worry, it’s never too late to learn!), let’s dive deeper into understanding this unique term.

Embarking on the 에볼루션파워볼 파싱알 Journey

Embarking on the journey of can seem a bit daunting at first. But believe me, it’s totally worth it! The more you learn about it, the more intrigued you’ll become. It’s a result of continuous evolution and improvement, which makes it even more fascinating.

The Influence of 에볼루션파워볼 파싱알

The influence of is seen far and wide. Its reach is so extensive that it has a significant impact on various spheres. Doesn’t that make you wonder about its potential and possibilities? What if you explored this realm a bit further? How will that transform your perspective?

Experiencing the 에볼루션파워볼 파싱알 Phenomenon

Gaining hands-on experience with is, by far, the best way to grasp its depth. And rest assured, it’s an experience like no other. You’ll be left not just amazed, but much more knowledgeable and informed. Who wouldn’t want that?

In conclusion, 에볼루션파워볼 파싱알 isn’t just another term; it’s a phenomenon shaping the digital world. So, step in, explore, and enjoy the journey!

Frequently Asked Questions

What is the significance of 에볼루션파워볼 파싱알?

The term holds immense value in the digital sphere, shaping various dynamics.

How do I embark on the 에볼루션파워볼 파싱알 journey?

Start with basic understanding and gradually delve deeper. It’s a journey worth embarking on!

Can 에볼루션파워볼 파싱알 impact my life?

Absolutely! It has the potential to transform different spheres of life, influencing decisions and actions.

How is 에볼루션파워볼 파싱알 evolving?

It is continually evolving and improving, making it an intriguing phenomenon to follow.

Why should I experience 에볼루션파워볼 파싱알?

Experiencing 에볼루션파워볼 파싱알 can enhance your understanding, increase your knowledge, and offer a whole new perspective.

  • October 15, 2023

Contemporary Collegiate Style: Tips for Styling Your Polo Jacket Uniform

How to Style Your Polo Jacket Uniform

From the halls of Harvard and Yale to fraternity keggers, polo shirts are inexorably linked with contemporary collegiate style. This makes them a staple in crew uniforms.

Look for a shirt that is made of high quality fabric. Blended fabrics offer good durability and stain resistance at a low price point. Avoid shirts with contrasting logos as they will look dated a few years from now.

Basic Plackets

For a simple, classic look that works anywhere from the office to the field, go with basic plackets. These use less fabric and stitching for a more cost-effective option, while still giving the shirt a tailored appearance. Interfacing in the placket and buttons that are cross-stitched create a more finished, professional look as well.

Originally, polo shirts emerged from the game of tennis, which was traditionally played in a get-up known as “tennis whites.” This included flannel pants and dress shirts (with rolled up sleeves), a style that is a bit more formal and a little less practical for an active sport like tennis.

The most common type of polo is made from pique, which is a densely-woven, tightly-woven cotton that offers some substance and structure to the shirt. This style is breathable, and a good choice for hot weather. Polo shirts made with a pique weave tend to be more expensive than others. However, a pique fabric provides superior wearability and a more refined appearance.

Set-In Plackets

A set-in placket is the style of placket used in most polo jacket uniforms. It features a collar that is formed by a separate piece of fabric, often a ribbed knit. Some styles use a self-fabric collar, which uses the fabric that is on the body of the shirt for the collar.

The placket has two to three buttons and can be worn buttoned or unbuttoned. Some shirts have special placket details such as a grosgrain ribbon, contrasting stitching or an angled bottom seam. Ladies shirts may have an elongated placket or snaps instead of buttons.

Polos have a polished and comfortable appearance that makes them ideal for work uniforms. Embroidery adds a smart touch that helps your company or group stand out in the crowd. Logo placement is usually on the left chest although it can be positioned on the right side if a pocket is located on the left. Individual names can also be embroidered on the front if desired.

Set-On Attached Plackets

Shirts with set-on attached plackets use more fabric than the basic placket because the interfacing is sewn separately and then added to the body of the shirt. This gives the shirt a more tailored appearance and is used in higher-end polos.

Sales and service uniforms are a step up from casual wear and need to look polished. Consider outfitting your sales team in customized polo shirts embroidered with the company logo paired with dress pants and leather shoes.

Work polos can be adorned with a logo across the front of the shirt, or on the left or right sleeve if a pocket is included on the garment. Logos can also be embroidered under the collar or on the back of the shirt. Some brands have different requirements and restrictions for logo placement, so check with the brand to determine their logo placement options.


The buttons on a polo jacket can be made from a wide range of materials and dyed to match the shirt. They may also be embroidered to create a fashion-forward look. Some shirts feature a pocket on the chest, but many sartorial purists think that a polo should never have a pocket unless it’s secured with a button to stay closed.

Some polo shirts have a collar that is a separate piece of fabric from the body of the shirt, usually a ribbed knit. Other polo styles have what is called a “self fabric” collar, which is a neckline that is made from the same fabric as the body of the shirt.

Polo shirts, when embroidered with your company logo, are perfect for dressing up casual events such as trade shows or county fairs. They also look professional and are ideal for helping your company stand out from the competition at corporate events and public meetings.

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  • October 14, 2023

Diving into the Enthralling World of Overseas Football Broadcasts

Dive Deep into 해외축구중계 World

If there’s anything that brings the world together, it’s the love of sports. One sport, in particular, stands head and shoulders above the rest – football or as some likes to call it – Soccer. Especially, in South Korea, 고비스축구중계(overseas football broadcasts) have earned massive popularity.

The Allure of 해외축구중계

Have you ever asked yourself, “Why is 해외축구중계 so captivating?” Well, the answer is simple. The excitement of watching your favorite teams from the English Premier League, La Liga, Bundesliga, or Serie A playing in a live match is incomparable. It’s the anxiety, the thrill, and the suspense of the simultaneous attack and defense that has people glued to their screens. For many South Korean soccer fans, these are not just games, they are almost like a festival.

How 해외축구중계 Connects the World

Have you noticed how football can unite people from all over the globe? 해외축구중계 serve as a bridge, connecting people despite cultural, geographic, or linguistic differences. For instance, during a , you will see fans cheering for their favorite teams regardless of nationality, always ready to celebrate a good goal or mourn a disappointing loss.

Why You Should Watch 해외축구중계

Are you a fan of 해외축구중계 yet? If not, then you must surely give it a try. Besides the excitement and adrenaline rush, 해외축구중계 also gives you a chance to learn more about different cultural aspects as football differs from country to country. So, what are you waiting for? Get ready to dive into the amazing world of 해외축구중계 today!

In conclusion, 해외축구중계 offers a unique blend of excitement, unity, and cultural experience. It is not merely about the competitive elements of the game but also encompasses a larger sphere of social, cultural, and global engagement.


Q1: What is 해외축구중계?
A1: 해외축구중계 is the Korean term for overseas football broadcasts.

Q2: Where can I watch 해외축구중계?
A2: You can watch 해외축구중계 on a variety of platforms, including .

Q3: Why is 해외축구중계 popular?
A3: 해외축구중계 is popular due to the excitement and unity that football brings, irrespective of country or culture.

Q4: Is 해외축구중계 different from regular football broadcasts?
A4: While the game remains the same, 해외축구중계 often highlights international teams and players that South Korean audiences may not be familiar with.

Q5: Can 해외축구중계 help me learn about different cultures?
A5: Yes, 해외축구중계 gives you a great opportunity to learn about the diverse ways in which football is approached and celebrated globally.

  • October 14, 2023

Elevate Your Style with Jacket Kurtis

Jacket Kurti Design

A jacket style kurti is an excellent option for winter weddings and other occasions that call for heavy dressing. Its high collar looks amazing with its velvet finish and makes you look smart and beautiful.

You can find a variety of kurtis with jackets in cotton and other fabrics like rayon on Libas. Choose a colour and design that matches your personality.


Kurtis with jackets can be found in all sorts of colours and designs. You can even find embroidered and long jackets for kurtis online that look grand on occasions like weddings. The best thing is that you can browse through multiple designs, compare prices and check reviews before making a buying decision. You can also pay for your kurtis using a credit or debit card, UPI, or cash-on-delivery.

The latest trend in jacket kurti design is the striped one. Striped kurtis look stylish and smart, and they are great for those who want to look taller and more elegant. You can pair them with pants or ankle-length tights to make the outfit more formal. They also come in different lengths, so you can choose one that is suitable for your height.


The fabric of the kurti and jacket is extremely important. The right fabric will keep you comfortable and stylish at the same time. Look for fabrics that are breathable and soft against the skin. They should also be wrinkle-free.

Kurti with jacket pattern is perfect for wedding functions and other events that require a classy outfit. It can even be worn to work. It can easily be paired with a straight back hairstyle and dark lip color to complete the outfit.

Choose darker tones for kurti with jacket sets to add depth and dimension to your outfit. This will elongate your figure and look slimming. Pair this with a belt to enhance your waistline. A contrasting color belt will also be great to complement the overall look.


A great way to enhance your Kurti is by wearing it with a jacket. You can find many options for jacket-style Kurtis online. These types of Kurtis are perfect for a variety of occasions. Some even come with short and long sleeve jackets.

Vibrant and eye-catching prints have been popular in kurtis lately. Whether it’s floral, geometric, or tribal, these prints add a splash of color and personality to your outfit.

Try a navy-blue A-line kurti with a denim jacket for a fashionable look. Pair it with strappy heels and a designer clutch to complete your look.


Fancy sleeves add the finishing touch to a kurti. They come in a variety of styles and extend up to the elbow and flatter the end for an uber-chic look.

One of the most popular sleeve designs is cold shoulder sleeves. They allow a peek of skin and are stylish enough for casual wear.

Another trending sleeve design is bell-like sleeves. They are wide at the cuff and narrow near the shoulder line for a unique look.

Adding sequences, beads, pearls, or a combination of all adds up to the beauty of a kurti. Pleats at the hemlines, sleeves, or necklines are also easy fashion accessories. You can try them with a solid-colored kurti for a classic look. Or, you can experiment with a printed kurti with pleated sleeves for an eye-catching look.


Embroidered jackets for kurtis are a fresh take on prevailing silhouettes like Anarkali, A-line, and fit & flare kurtis. Pair them with a pair of jeans or dhoti pants and accessorise with long oxidised-toned ear accessories to complete your look.

A sleeveless satin short kurti and net embroidered jacket set is the perfect pick for winter weddings. The contrasting colour combination and the velvet finish make this outfit stand out in a crowd.

The key to achieving limitless clean energy is finding a way to produce more energy from fusion than it takes to generate it. Scientists have been working towards this goal for decades, with their efforts focused on tokamak reactors and stellarators that confine deuterium and tritium plasma magnetically. However, there are still significant engineering challenges to overcome.

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  • October 14, 2023

Unveiling the Power of Parsing in Evolution Powerball

Introduction to Evolution Powerball Parsing

Understanding what 파워볼 파싱 is about begins with understanding what the Evolution Powerball () is. Simply put, it is a fitness tool with a gyro mechanism. As you may have noticed, ‘parsing’ is not a concept traditionally associated with fitness equipment. However, in the context of 에볼루션파워볼, ‘parsing’ refers to the process of extracting and analyzing data from the device to study patterns, behaviors, and performance.

Understanding the Evolution Powerball

A thrilling part about using the 에볼루션파워볼 is that it is not only physical but also digital. It is an embodiment of how modern technology can transform traditional fitness. However, to take full advantage of this sophisticated piece of equipment, understanding it is crucial.

The Role of Parsing in the Evolution Powerball

Parsing or data extraction in the context of 에볼루션파워볼 plays a vital role. It provides users with insights into their performance and progression. As a user, understanding these details can help you leverage the 에볼루션파워볼 fully.

Benefits of Parsing in Evolution Powerball

Why is 파워볼 파싱 crucial in 에볼루션파워볼? Simply put, by analyzing the extracted data, users can monitor their performance in real-time. This innate capacity to track your progress enhances your workout efficiency and maximizes your potential.

Wrapping Up

Scraping and analyzing 에볼루션파워볼 data helps users adapt their exercise programs to their needs. Regardless of your fitness level, 파워볼 파싱 presents a unique opportunity to set, track, and reach your fitness goals.

FAQs about 에볼루션파워볼 파싱

Q1: What data can be parsed from the 에볼루션파워볼?
Answer: The 에볼루션파워볼 can provide data such as the speed of rotation and the duration of the exercise, among other things.

Q2: How does 파워볼 파싱 improve my workouts?
Answer: 파워볼 파싱 allows you to track progress, adjust workouts in real-time and maximize workout efficiency.

Q3: Is 파워볼 파싱 suitable for beginners?
Answer: Yes, 파워볼 파싱 is helpful regardless of your fitness level as it helps set, track, and reach fitness goals.

Q4: How can I start 파워볼 파싱 with 에볼루션파워볼?
Answer: The device comes with software that uses the parsing concept to extract data.

Q5: Can I use the 에볼루션파워볼 without 파워볼 파싱?
Answer: Yes, you can use the 에볼루션파워볼 for exercise without parsing data. However, 파워볼 파싱 helps you get the most out of your workouts.

  • October 12, 2023

The Versatility of Varsity Jackets

How to Design Your Own Varsity Jacket

Originally trophy items that were awarded to athletes, this iconic piece of clothing has since gone beyond the world of sports and into high fashion. Brands like Ralph Lauren and streetwear giants Stussy have reinterpreted this jacket.

Typical embellishments include the student’s first name, last name, graduation year and symbols representing their achievements.

Choose Your Colors

A varsity jacket is the epitome of style and sophistication. This timeless classic was first awarded to students who excelled in sports, but has since become a fashion staple that transcends fleeting trends.

The most popular design of a varsity jacket features contrasting colors for the body and sleeves. For a more unique look, experiment with different color combinations that resonate with your personal style. You can also add a monogram or embroidered symbol for a more personal touch.

After completing the embroidery and patches, it’s time to sew the jacket together. Be sure to use a serger or zigzag stitch, as this will ensure that the fabric does not unravel during washing. Once the sewing is done, wash the jacket inside out to protect the embroidered or patched surface from friction and abrasion. Remember to use a cold water setting and to wash with other dark-colored items, as this will minimize the risk of color bleeding and fading.

Select Your Patterns

The classic varsity jacket is a timeless piece that will never go out of style. It’s a great way to show your school spirit, and it looks great when paired with a pair of jeans or a simple t-shirt. It’s also a good choice for any extracurricular activities you participate in, such as music, sports, or a club. You can even include a symbol above the pockets, like a mascot or a musical instrument patch.

The first step is to draft the pattern for your jacket body and sleeves, as well as the collar, cuffs, and waistband. Once the pattern is complete, cut the pieces out of your selected fabrics and sew them together. You’ll also need to add snaps or buttons for the front closure and, if you want, additional embellishments such as chenille letters and embroidered patches. After the sewing is completed, add the ribbed knit base and trim to your jacket body and sleeves.

Add Your Name

Traditionally, your name would be embroidered across from the second snap on the jacket front. The first snap holds an academic letter if your jacket already has one and is also where extracurricular pins can go, such as music, sports or other programs you participate in that earn you a patch.

We offer a wide selection of twill, felt and embroidery patches to choose from that can be applied in up to four locations on the jacket. These include a range of different flags, badges, mascots and athletic patches that represent your school’s sporting achievements.

We can also add a number patch to your jacket that represents your expected date of graduation or your player jersey number and a custom patch representing any other extracurricular activities you take part in. Adding these will make your personalized high school jacket truly unique and stand out from the crowd. For more information, please contact us or get a quote now.

Personalize Your Jacket

The varsity jacket is a classic, timeless fashion piece that embodies an all-cool attitude and always-young spirit. While it was originally a trophy item awarded to the winners of varsity competitions, today you don’t have to be a jock to get your hands on one. In fact, many extracurricular activities can earn you a letter (traditional sports aside). It’s possible for students who excel in marching bands, drama clubs or robotics to achieve a varsity jacket.

Regardless of their sporty origin, the jacket has earned the right to become part of the streetwear culture thanks to tastemakers like Virgil Abloh. Brands such as Opening Ceremony, Stadium Goods and a host of others have refreshed the style so it can fit seamlessly into the fashion conversation.

Coastal Reign offers a wide range of varsity jackets that can be personalized to your team’s specifications. Choose from a wide selection of colors, fabrics and sizes to find the perfect jacket for your group.

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  • October 12, 2023

Functional and Stylish Jacket Sewing Patterns for Every Occasion.

Jacket Sewing Patterns – Style and Function in One

When it comes to jacket sewing patterns, function takes precedence over form – so thick fabrics and practical features are the norm. But that doesn’t mean they can’t be stylish too!

Discover our range of stunning jacket-dresses in a variety of styles. Take the workwear-inspired Wrap jacket, for example. It’s fitted with front pockets and a fabric tie for added security.


The Pilvi coat dress is a fitted and flattering dress sewing pattern that is designed to look like a coat with long sleeves, double breasted button closure and notch lapels. It has a belt at the waist and handy patch pockets sewn in the front seams. The dress is made for knit fabric and can be worn over a tank top or shirt.

This is one of the five basic garment patterns in Lotta’s Everyday Style book. The other pattern we love in this book is the Esme tunic. Both the Pilvi coat and the Esme tunic are modeled in the book by women over 50, which we really appreciate!

The Pilvi is easy to make, but it’s important to trace/cut all the pieces before you start sewing. When you cut the sleeve and back neck facing, don’t forget that they attach to the front jacket piece at the edge where it folds back. If you skip this step, the sleeve and neck facing will be 2 inches shorter and won’t line up with the front pieces.

Wrap jacket

The Wrap jacket is a simple, versatile pattern that can be sewn in woven or jersey fabric. The pattern includes separate front pattern pieces for woven or knit fabric options and two collar styles. It’s an easy sew that will look dressy in a brocade and casual in denim, depending on your choice of fabrics. It’s also great for beginners because it requires no hand sewing and no pattern marking.

It’s designed to be a comfy and cozy layer in the office or at home, with raglan sleeves and clean lines for a mix of comfort and put-togetherness. The pattern is available in sizes XS to XL adults, and includes a fully-lined, oversized wrap belt. It’s a climate-positive garment, made in Spain from fabrics sourced from European regenerative agriculture farms and fully circular.

This paper sewing pattern from The Assembly Line is slightly oversized, with a crossover front that features matching fabric ties and large front pockets. It’s a versatile pattern that can be styled with jeans or our Almost Long trousers. It’s recommended for medium to heavy weight fabrics such as denim, cotton twill, and lightweight canvas. Sizing is based on chest measurement. The pattern is carefully packaged in an envelope and includes step-by-step sewing instructions.

Ray Darten jacket-dresses

Ray Darten’s beautiful African print jacket-dresses are the perfect combination of style and versatility. Each outfit can be worn three different ways – as a dress, a skirt, or a tunic – giving you the freedom to create countless looks for any occasion. Made with the highest-quality materials, these stunning jacket-dresses are comfortable, breathable, and durable, making them the ultimate choice for any wardrobe. Choose the Fikayo African Print Maxi Jacket-Dress for a formal event, or the Purple and White Africa Print Jacket-Dress for a casual brunch with friends. The beautiful patterns and bold colors in these outfits will make you feel confident and beautiful, no matter how you wear it.

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  • October 11, 2023

Traditional Indian Jacket Design for Garba and Dandiya Raas Dancing

Crosia Jacket Design in Hindi


Kediyu is an outfit worn by men for the performance of Garba and Dandiya Raas. The kediyu is a short frock-type kurta that is embroidered with intricate designs through zardozi. The embroidery often showcases geometric, wavy, and humanoid motifs. In addition, the kediyu can be decorated with elaborate mirror work and tassels.

The kediyu is worn above a pair of chorno, which are pants that look like stitched dhotis. The chorno can either have strings that tie around the waist or elastic. The kediyu fits snugly around the chest and flares out from the waist and hips, which adds a special element to the dancing.

The kediyu is traditionally made of cotton because the physical activity involved in the dance makes the wearer sweat. Moreover, cotton is a cool and absorbent textile that helps keep the torso and limbs cool. The kediyu can be worn in various colors and embellishments, but it is usually kept simple to let the intricate designs of the shirt shine.

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  • October 11, 2023

Efficient and Cost-Effective Solutions for Jacket Tank Designs

Jacket Tank Design for Food and Beverage Industries

Jacketed tanks keep materials warm or cool by circulating heating and cooling fluids around the tank. They are used for various applications, including chocolate, liquid food blending and aging, ingredient mixing, and batch sterilization.

Conventional jackets come in a wide range of sizes and pressure ratings. They can be fitted with baffles and zones to improve thermal control. However, these components increase weight and cost.

Dual-walled jackets

Conventional jackets can be zoned and baffled to deliver uniform temperature regulation, but these extra components add weight and increase costs. Also, as the surface fabric clings to sweat vapor, it slows its movement to the outside and causes a clammy feeling in your skin.

A dimple jacket design, on the other hand, uses a large area of equal-spaced depressions to create a heat exchange mechanism. Cold water or hot steam passes in and around the depressions to keep tank contents cool or warm, respectively. This can save a process step, reducing production cost.

Most of the jackets in this guide are filled with down, which is warmer than synthetic insulation. However, down loses its warmth when wet. Fortunately, many companies make hybrid designs that combine down with synthetic fill for optimal warmth and durability. These include Patagonia’s Storm10 and Rab’s Torrentshell.

Internal coils

Many food and beverage industries rely on jacketed tanks to heat or cool materials. These tanks can be used for milk and fruit juice heating or cooling, ingredient blending, ice cream production, and more. These tanks are usually fitted with internals, which can improve the heat transfer efficiency. They can also reduce the amount of energy needed to operate a tank.

Depending on the design, internals may include baffles that alter flow patterns and increase turbulence. They can also be equipped with agitating nozzles, which can help with heat transfer in the liquid inside. In addition, a variety of internals are available for different temperature ranges.

These types of jackets can be either immersed in the liquid or fastened to the outside of a tank, called limpet coils. In the latter case, throttling the utility makeup flow instead of the jacket or coil flow can prevent fouling and maintain a constant fluid velocity across the heat exchange surface.

Double-wall jackets

A double-wall tank is a safer option for storing corrosive or polluting chemicals such as chemical fertilizers, fuels, nitric acid, ferric acid, and hydrochloric acid. It’s also an excellent choice for a storage tank that will be subject to continuous operation or transport. The second skin prevents leaks and retains any liquids that might escape from the first jacket in the event of an accident.

The outer jacket is made from dimple plate and the inner space is filled with a special heat transfer fluid, Bucomastic, to improve its thermal performance. This system is particularly suitable for retrofitting existing tanks.

This jacket is a top pick for warmth, comfort and weather protection. Its waterproof construction keeps you dry and the insulated fill helps keep your body warm all day. It features the latest iteration of Columbia’s Omni-Heat Infinity gold dot technology that uses a reflective surface to retain your body’s heat and eliminate cold spots. Its double-layered construction also blocks wind to keep you warmer.

Conventional jackets

Conventional jackets provide a full perimeter of heating or cooling around a vessel. They are a good choice for smaller, lower pressuretemperature applications. COMPRESS makes it fast and easy to design conventional jackets using the rules of Division 2. The higher allowable stresses in this section allow for thinner inner shell walls, which improves heat transfer.

Plate Coil Jackets

Plate coil reactor jackets are fabricated from whole pipes, which are strapped to the vessel. This type of jacket offers superior strength, up to 750 psi. They can be used for liquid heat transfer and high-temperature industrial processing. Plate coil jackets are a bit more expensive than other jacket types, but the increased strength can save money in the long run on vessel replacement costs. They also require good bonding to prevent insulating gaps between the plate coil and the vessel. A major drawback of plate coil jackets is their susceptibility to fatigue failure due to rapid thermal cycling.